Comprehensive Cancer Screening
A 55-year-old patient visits their primary care physician concerned about cancer symptoms.
They undergo a comprehensive screening that includes multiple tests and factors.
Given Information:
• Patient has family history of cancer (mother diagnosed at age 60)
• Shows mild symptoms: fatigue and weight loss
• Lives in area with 1.2% cancer prevalence
• First screening test shows suspicious results
• Follow-up biopsy is recommended
Base Rate Information
General Population: 1.2% cancer rate
Family History: 3× increased risk
Patient's Prior: 3.6% (1.2% × 3)
Screening Test Characteristics
| Test Type | Sensitivity | Specificity |
|---|---|---|
| Initial Screening | 92% | 87% |
| Follow-up Biopsy | 95% | 93% |
Complete Bayesian Analysis (Click to expand)
Establish Prior Belief
Calculate initial probability of cancer before any testing:
Update with Initial Screening Test
Patient tests POSITIVE on initial screening. Update beliefs:
Update with Follow-up Biopsy
Biopsy also comes back POSITIVE. Final update:
Final Diagnosis Probability
Recommendation: High confidence in cancer diagnosis. Immediate treatment planning required.
Exercises
Exercise 1.1: Understanding Bayesian Updates
Question: Explain why the probability increased from 3.6% (prior) to 20.9% (after first test) to 96.2% (after second test). What role does each piece of evidence play?
Exercise 1.2: Alternative Outcome
Scenario: Suppose the initial screening test came back NEGATIVE. What would the patient's cancer probability be after that single negative test?